Photo of Stanley Falkow

Stanley Falkow

  • National Medal of Science
  • Biological Sciences
For his monumental contributions toward understanding how microbes cause disease and resist the effects of antibiotics, and for his inspiring mentorship that created the field of molecular microbial pathogenesis.

Stanley Falkow on overcoming his fear of public speaking

In the 1950s, a medical technologist collected stool samples from surgery patients, encapsulating the frozen feces into pills for ingestion during recovery. The human digestive tract hosts about 1,000 species of microorganisms needed for healthy digestion. Stanley Falkow believed so-called “fecal reconstitution” could repopulate these gut microbes, typically killed off by post-surgery antibiotics. The experiment, ahead of its time, angered a hospital administrator, who – upon realizing Falkow fed patients their own feces – fired the him on the spot.rnrn“It’s a repulsive thought,” Falkow, an emeritus professor at Stanford University School of Medicine, told the New Yorker in 2014, “and people are still repulsed by it.”rnrnThrough his research, Falkow became an early advocate of the “fecal transplant,” a process of introducing gut bacteria from a healthy person into a sick person’s intestines. Later, Falkow’s “molecular Koch’s postulates” offered an explanation for how genes in these microorganisms contribute to the spread of disease.